Abstract

EFFECT OF ALOE VERA GEL EXTRACT ON OXIDATIVE ENZYMES IN ALLOXAN–INDUCED DIABETIC ALBINO-RAT TESTIS

Dr. Ravi Naik Mude* and Bandela Vijayudu

Abstract

The present study was aimed to evaluate the therapeutic potential of Aloe vera by assaying the activities of selective oxidative enzymes in Alloxan induced diabetic oxygen free radicals have been suggested to be a contributory factor in complications of Type-1 diabetes mellitus. Aloe vera leaf gel extract administered orally to different groups of rat at a dose of 300mg/kg body weight for three weeks, Albino-Rats were divided into four groups. Each group consists of six rats. Normal Rats, Normal Rats + Aloe vera, diabetic + Aloe vera (Alloxan 40mg/kg body weight). In this study, work was under taken to evaluate the oxidative enzymes activity of Aloe vera gel extract on testis tissue oxidative enzymes, Glucose-6-phosphate dehydrogenase(G-6-PDH), Lactate dehydrogenase(LDH), Succinate dehydrogenase(SDH), Glutamate dehydrogenase(GDH) in Alloxan induced diabetic rats. G-6-PDH, SDH, GDH, activities were decreased in diabetic albino-Rats. Where as LDH activity was increased. Oral administration of Aloe vera gel extract to diabetic Rats showed significantly reversal of disturbed oxidative enzyme system. The findings of this study indicate that the administration of Aloe vera resulted in a better oxidative profile levels in both normal and diabetic rats.

Keywords: Diabetes, Aloe vera, Alloxan, oxidative enzymes, testis, male rats.