Abstract

“ANTI-ASTHMATIC STUDY OF ETHANOLIC LEAVES EXTRACT OF BIOPHYTUM SENSITIVUM L. IN ASTHMA INDUCED GUINEA PIGS”

Prof. Dr. Mathew George*, Prof. Dr. Lincy Joseph and Umesh Kumar

Abstract

The main objective of this study was to investigate the antiasthmatic activity of leaves of Biophytum sensitivum L. in guinea pigs. The ethanolic extract of Biophytum sensitivum L of two doses-100 mg/kg & 200 mg/kg body weight was selected for the study. The preliminary phytochemical studies showed the presence of steroids, phenolic groups, cardiac glycosides and flavonoids. The toxicity study showed that a oral dose of 2000 mg/kg body weight of ethanolic extract of leaves of Biophytum sensitivum L. is non toxic to guinea pigs and was compared with the standard drug 'Chlorpheniramine maleate' when given intraperitoneally. It was concluded from the studies that ethanolic extract of leaves of Biophytum sensitivum L possess a significant dose dependent anti-asthmatic activity.

Keywords: Biophytum sensitivum L, Antiasthmatic activity, Chlorpheniramine maleate.