Abstract

RELEASE STUDY OF STAVUDINE LOADED TO CHEMICALLY GRAFTED NOVEL POLYMER CHITOSAN-G-HEMA

Rakesh Kumar Pradhan*, Shaktiprasad Pradhan, Ranjit Mohapatra

Abstract

Current study involves the in-vitro release study of Stavudine from chemically grafted co-polymer Chitosan-g-HEMA. Chemical grafting of 2-Hydroxyethylemethacrylate onto chitosan was carried out to improve its solubility and relevance. The grafting procedure consists of surface activation followed by free radical graft polymerization of HEMA onto chitosan with benzoyl peroxide as an free radical initiator. Whole reaction was carried out at 70-80°C. To the polymeric chain HEMA was grafted terminally and covalently bonded. The grafting was confirmed by FTIR spectroscopy, XRD and the thermal property was studied by DSC. The drug (Stavudine) loading to the grafted co-polymer was performed and the percentage of drug entrapment was determined. The drug polymer interaction and in-vitro release of drug in phosphate buffer 6.8 and 0.1N HCl from drug loaded polymer was studied.

Keywords: graft co-polymer; chitosan; HEMA; free radical graft polymerization stavudine; swelling; in-vitro drug release.