Abstract

FORMULATION DESIGN AND EVALUATION OF CEPHALEXIN CONTROLLED RELEASE MATRIX TABLETS

B. Basanta Kumar Reddy*, Dr. K.E.V. Nagoji and Dr. Satyanarayan Sahoo

Abstract

The aim of the present work was to design controlled release matrix tablets of Cephalexin by incorporating the drug in a matrix made up of using combination of low concentration of hydrophobic polymer and hydrophobic polymers, to study their release pattern and release mechanism of the drug from matrix tablets upto 12 hours. Hydrophobic polymer is the rate retardant material, but different combinations with hydrophilic polymer increase the release rate to establish intended drug release up to 12 hours. Matrix tablets were formulated with the combination of hydrophobic to hydrophilic polymers in the ratios of 1:1, 1:2, 1:3 and 1:4. F1 to F4 formulation were prepared with ethylcellulose (EC) and hydroxypropyl methyl cellulose (HPMC K4M), F5 to F8 were prepared with EC and HPMC K15M and F9 to F12 were prepared with EC and HPMC K100M. Designed matrix tablets were evaluated for various pre-compression and post-compression parameters. F4 is the optimized formulation, showed 100.34% release at the end of 12 hours as it showed good release rate profile compared to all formulations. Drug released pattern followed zero order with non-Fickian diffusion method.

Keywords: Matrix former, Controlled release tablet, Release Kinetics, HPMC, Ethyl cellulose.