Abstract

APPLICATION OF OXAZOLONE IN SYNTHESIS OF NEW HETEROCYCLE CONTAINING 5-IMIDAZOLONE MOIETY AS POTENT PHARMACOLOGICALLY ACTIVE SCAFFOLD

*Anjani Solankee

Abstract

In a search of new antimicrobial agents, a new series of 1-[4'-(Nmethyl- N-acetyl amino) phenyl] -2-phenyl-4- (phenyl/ substitutedphenyl/ heterocyclic) benzylidine-5-imidazolones (3a-j) have been prepared with the reaction of oxazolones (1a-j) and 4- amino-N-methyl acetanilide (2). The chemical structures of all newly synthesized compounds were established on the basis of their FTIR, 1H NMR as well as elemental analysis. All the compounds were screened for their in vitro antimicrobial activity against selected pathogens such as Staphylococcus aureus [MTCC-96], Bacillus subtilis [MTCC-441], Escherichia coli [MTCC-443] Salmonella paratyphi-A [MTCC-735] as bacterial pathogenic strain and Fusarium solani [MTCC-350] as fungal pathogenic strain. Most of the compounds showed appreciable antimicrobial activity against the all tested strains. Among the synthesized compounds 3b, 3c, 3e, 3h and 3j displayed significant antimicrobial activity and said to be the most proficient members of the series.

Keywords: 4-Amino-N-methyl acetanilide, oxazolones, 5-imidazolones, antimicrobial activity.