Abstract

SYNTHESIS OF NOVEL TETRAZOLO AND TRIAZOLO [1, 2-e] IMIDAZOLO [4, 5-b] QUINOXALINE DERIVATIVES AS ANTIMICROBIAL AGENTS

T. Revathi, B. Srinivas, A. Sandeep and B. Prasanna*

Abstract

An efficient general method has been described for the synthesis of novel tetrazolo and triazolo[1,2-e]imidazolo[4,5-b] quinoxaline derivatives 4(a-f) and 5(a-f) by the reaction of (1H)-tetrazol-5-amine and (3H)-1,2,3-triazol-4-amine with substituted 2,3-dichloro quinoxaline in DMF solvent and added a catalytic amount of K2CO3. These analogs were evaluated for their antimicrobial activity against Bacillus Subtillis, Staphylococcus aureus (Gram positive bacteria) Escherichia Coli (Gram Negative bacteria) and Aspergillus niger, Candida albicans (fungi).The analogs 4d, 4f, 5d and 5f were identified as potent antimicrobial agents. Structural elucidation of all the newly synthesized title compounds has been established by the spectroscopic data IR, 1 HNMR, 13 C NMR, mass and elemental analysis.

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