Abstract

EFFECT OF HYDROPHILIC POLYMERS ON DISSOLUTION OF NIMODIPINE

Esmat E. Zein El Dien, Nageh A. El Mahdy and Wesam Samy*

Abstract

Nimodipine (NMD), a calcium channel blocker, has a low oral bioavailability due to poor solubility and insufficient dissolution rate. In order to improve drug´s solubility, various techniques were employed, solid dispersion(SDs) for drug and its formulation by solvent evaporation technique were used . Formulations so prepared were estimated by differential scanning calorimetry (DSC), IR and were investigated for, solubility studies. The dissolution of the prepared formulations prepared with polymers PloxamerF68, Eudragit Epo, HP-beta- CD were tested, All polymers in tested formulations showed improvement in the dissolution rate ofthe drug.

Keywords: Nimodipine, solvent evaporation, polymers, solid dispersion, dissolution.