Abstract

EVALUATION OF THERAPEUTIC EFFECTIVENESS OF ULINASTATIN IN ACUTE PANCREATITIS

Asif Rasheed*, Dr. S. Akbar Hassan, Faiq Unnisa, Rukhaiya Fatima, Sana Tahreem, Adiba Saher6

Abstract

OBJECTIVES: To evaluate the effectiveness of Ulinastatin in Acute Pancreatitis. To reduce mortality and morbidity in severe pancreatitis. To reduce hospital stay thereby reducing cost of care. To spread awareness among the healthcare and allied profesionals on the effectiveness of Ulinastatin. METHODS: An observational study is done to evaluate the effect of addition of Ulinastatin to the standard treatment and its efficacy to reduce the serum amylase and lipase levels in patients with Acute Pancreatitis v/s patients not given Ulinastatin but standard treatment only. RESULTS: 60 patients with Acute Pancreatitis following the inclusion criteria set up (n=60). Out of 60 selected patients (n=60), 30 patients in a group were given Ulinastatin while 30 cases were retrospectively collected when ulinastatin was not used (past records). The calculated F value for serum amylase is greater than the table value for 60 subjects i.e, serum amylase F value 10.44 greater than table value 10.13,thus showing that there is a significant change in serum amylase levels in Ulinastatin group. CONCLUSION: This study revealed that the efficacy of the drug Ulinastatin improve serum amylase and lipase levels significantly thus reducing the duration of acute insult and preventing further complications. Out of 30 subjects in Ulinastain group, only 3 patients developed mild complications. The incidence of complications was higher in the group which were not given the drug compared to the ulinastatin group. This study concludes that the addition of ulinastatin to the standard treatment reduce mortality and severity of the symptoms associ-ated with severe pancreatitis patients thereby reducing hospital stay and cost of care.

Keywords: Ulinastatin, Acute pancreatitis, amylase, lipase.