Abstract

NANOSUSPENSION-AN EFFECTIVE APPROACH FOR SOLUBILITY ENHANCEMENT

Ch. Srinivasakumari*, P. Sireesha, S. Sheema Nafees, P. Jagadeesh, S. Dasthagiri and K. Syad Basha

Abstract

Solubility is an essential factor for drug effectiveness, independent of the route of administration. Poorly water soluble drugs show major problems for drug formulation. There are number of conventional approaches to resolve the problems of low solubility and bioavailability but with many limitations so nanotechnology is used to resolve the problems associated with these conventional approaches for solubility and bioavailability enhancement. Nanotechnology is defined as the science and engineering carried out in the nanoscale that is 10-9 meters. Nanosuspensions are a part of nanotechnology which is defined as very finely colloid, biphasic, dispersed solid drug particles in an aqueous vehicle, size below 1μm without any matrix material stabilized by surfactants and polymers. Nanosuspension can be administered through various routes like oral, topical, parenteral, ocular and pulmonary routes. Preparation of nanosuspension is simple and applicable to all drugs which are water insoluble. A nanosuspension not only solves the problems of poor solubility and bioavailability but also alters the pharmacokinetics of drugs and thus improves the drug safety and efficacy. This review article describes nanosuspension advantages, disadvantages and its preparation methods followed by evaluation and applications in pharmaceutical field.

Keywords: Nanotechnology, Nanosuspensions, Solubility, Bioavailability, Surfactants and Polymers.