Abstract

INSILICO IDENTIFICATION OF POTENT PPAR AGONISTS FROM Rheum Emodi PLANT COMPOUNDS

Dr. Radhika Ravindran* and Dr. Sudarsanam Dorairaj

Abstract

PPARs are members of the nuclear hormone receptor super family that bind to specific DNA response elements as heterodimers with the retinoid X receptor. The endogenous activators of all members of the PPAR family are a variety of fatty acids, which suggests that the PPARs are highly involved in lipid metabolism. The role of PPAR in combating diabetes has provided us the rationale to carry out structure based drug design studies. Docking results of PPAR γ with emodin, chrysophanol and the drug glibenclamide are performed using Glide. The finding suggests that both the components of R.emodi could serve as PPAR-γ agonists.

Keywords: PPAR, Type 2 diabetes, Docking, Chrysophanol, emodin, agonists.