Abstract

SYNTHESIS AND ANTIMICROBIAL EVALUATION OF 2,6-BIS((E)-(2- HYDROXYNAPHTHALEN-1-YL)DIAZENYL)-1-SUBSTITUTED PHENYL-1,4-DIHYDROPYRIDINE-3,5-DICARBALDEHYDE

Milind Maharu Patil* and Shankarsing Sardarsing Rajput

Abstract

Unsymmetrical and symmetrical bis (heteroaryl) azo dyes were prepared by diazotization-coupling reactions in low to good yield. A series of new azo coupled derivative of N-substituted cyclic imides were prepared by diazotization-coupling reaction. All the compounds were screened for their antimicrobial and antifungal activities. Most of the synthesized compounds have shown significant biological activity. Based on our experimental findings, the new substituted azo vinyl aldehyde derivatives containing cyclic imide moiety exhibiting excellent bactericidal and fungicidal potentials could be proposed for dyeing and antimicrobial finishing for silk, wool, cotton, and polyester fabrics. The structures of these compounds were confirmed by various analytical tools.

Keywords: diazotization, coupling reaction, azo coupling, cyclic imides, biological activity.