Abstract

EVALUATION OF DIURETIC POTENCY OF ROOT EXTRACTS OF HEMIDESMUS INDICUS IN RATS

Rathod M. L.*, Dr. N. R. Sheth, Dr. A. V. Dudhrejia, Dr. S. K. Parmar and Dr. S. D. Sanja

Abstract

Background and objectives: The plant Hemidesmus indicus syn. Sariba, Family- Asclepiadaceae, is a perennial, slender, laticiferous, prostrate or semi-erect, twining, wiry shrub. Root part of this plant is commonly used as tonic, alternative, blood purifier, diaphoretic, diuretic and skin diseases. Crude hydro ethanolic extract of root of Hemidesmus indicus (CHEERHI) was evaluated for its diuretic activity in a dose of 250 and 500 mg/kg body weight by oral route. Methods: Lipschitz model Results and interpretation: CHEERHI showed significant increase in urine volume along with increased excretion of sodium, potassium, creatinine and chloride ions as compared to control group. CHEERHI showed delayed diuretic effect (after 4 hours of administration) as compared to furosemide. Conclusion: It is diuretic and thus blood purifier.

Keywords: Hemidesmus indicus, Diuretic activity, Metabolic cage, Furosemide.