Abstract

ACUTE INTRAVENOUS TOXICITY STUDY OF DISODIUM EDTA IN SWISS ALBINO MICE

Manu Chaudhary*, Parveen Kumar, Satish Kumar and Vinoth Kumar M.

Abstract

The study was conducted to determine the acute toxicity of disodium EDTA upon slow intravenous injection in mice. The study was conducted at four dose levels and all doses were administered by slow injection in the lateral tail vein. All animals were observed upto 14 days after dosing for clinical signs of toxicity. Animals in the vehicle or disodium EDTA group showed normal gain in body weight. No clinical signs of pathological significance were recorded in this study. Mortality was not found in any group. Gross necropsy revealed that all organs appeared completely normal and were comparable to control in all the groups treated with disodium EDTA. Based on these observations, it was concluded that administration of disodium EDTA by slow intravenous injection does not produce any visible signs of toxicity upto doses of 120 mg/kg.

Keywords: Disodium EDTA, Elores, Acute toxicity.