Abstract

DEVELOPMENT AND CHARACTERIZATION OF TOPICAL DRUG DELIVERY SYSTEM CONTAINING NIOSOMES

Varsha M. Dhole*, Datta D. Shelgavkar, Vikram K. Rathore, Dr. S. D. Pande

Abstract

Niosomes are vesicular drug delivery system; it acts as a carrier and protects the drug from the internal environment. It has been also used because of its higher diffusivity in skin for promoting dermal delivery of drug which has to act topically. The aim of present study is to developed and characterise topical drug delivery system containing niosome by using antifungal agent. The antifungal agent widely used for the treatment of infection due to fungal species like Trichophyton rubum, Trichophyton mentagrophyts, Malassezia furfur etc. most of the antifungal drug are poorly water soluble. Sustained release of Niosomes can be applied to drugs with low water solubility since those could be maintained in the circulation via niosomal encapsulation. Niosomes were formulated by rotary evaporation hydration method by using phospholipids, cholesterol and Non ionic surfactant such as span and Tween. Primary placebo batches of niosome were prepared and evaluated for particle size and shape. Then octopirox loaded batches of niosome were prepared and evaluated for size, shape and Entrapment efficiency. For the delivery of niosome through skin topical dosage form i.e. cream was prepared. Evaluation of cream containing niosome was carried out for viscosity, measurement of pH, spreadability etc. the results obtained are shown in the present work. From the results it can be concluded that the formulation evaluated for the drug release of the optimized batch i.e. V- using o/w cream base, it was concluded that the drug release rate increases with its increasing concentration.

Keywords: Niosome, Octopirox.