Abstract

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET: A REVIEW

Pavitra Solanki*, Reena Singh and Vishnu Dutt Singh

Abstract

Over the past three decades, Orally Disintegrating Tablet (ODT) has gained much attention as a preferred alternative to conventional oral dosage form such as tablet and capsules. These dosage forms are placed in the mouth, allowed to disperse in the saliva, to produce a suspension which can be easily swallowed by the patient. In addition, patients suffering from dysphagia, motion sickness, repeated emesis and mental disorders prefer these medications because they cannot swallow large quantity of water. Further, drugs exhibiting satisfactory absorption from the oral mucosa or intended for immediate pharmacological action can be advantageously formulated in these dosage forms. Fast dissolving tablets are solid dosage forms containing drugs that disintegrate in the oral cavity within less than one minute leaving an easy-to-swallow residue. These dosage forms are placed in the mouth, allowed to disperse or dissolve in the saliva. The release the drug as soon as they come in contact with the saliva, thus obviating the need for water during administration. The aim of this article is to review the progress of the evolving technologies and super disintegrating agents in the formulation, manufacturing and evaluation of these tablets.Various modifications in the conventional evaluation and use of specialized instruments are found to be essential in the testing of these dosage forms. In the present review the formulation techniques and different technologies are discussed.

Keywords: Fast Dissolving Tablets, orally disintegration tablet, Freez drying, moulding.