Abstract

THE BIOTRANSFORMATION OF XENOBIOTICS IN THE ORGANISM OF CHILDREN WITH CARIES

*Luch?nskyi M.A., Luch?ynskyi V.M., Luch?nska Yu.I.

Abstract

The article presents data that show that children living in ecologically unfavorable areas manifest more severe course ekopatolohiyi which is reflected in an increase in the prevalence, intensity and activity of dental diseases. Reduced activity of enzymes detoxifying observed in children of the main group, confirms the deterioration of the efficiency of neutralization of xenobiotics in the first and second phases of biotransformation responsible for the conversion of lipophilic compounds in the hydrophilic reaction - capable of metabolites and prepare them for subsequent conjugation.

Keywords: children, dental caries, genetic markers, ecodetermined diseases.