Abstract

PUNICA GRANTUM L AND ZIZIPHUAS MAURITIANA MITIGATE ANEMIA IN CANCER

*Somayeh Afsah Vakili Ph.D and Dr. Meera Sumanth

Abstract

Back ground: Anaemia is interpreted as the decrease in the number of the red blood cells in blood or decline in the quantity of haemoglobin. Chemotherapy can engender various side effects such as bone marrow depression with low count of erythrocyte and haemoglobin which lead to anaemia. With conventional medical remedy, it isn’t always feasible to intercept and treat chemo- and radiotherapy side effects sufficiently. Hence the intent of this research was to perceive evidence if ayurvedic therapies can be a suitable and safe supportive to conventional drugs. Aim: To palliate the anaemia with Punica grantum L and Ziziphus mauritiana in cancer. Materials and method: Animals were divided into 12 groups of 12 mice. Group 1, 2, 3 mice served as normal, ehrlich ascites carcinoma control and standard (5- Flourouracil) respectively. Group 4, 5, 6, 7, 8, 9, 10, 11, 12 mice were treated orally with aqueous, ethanol, chloroform extract of Punica grantum L, Ziziphus mauritiana and combination of both plants 200 mg/kg b.w, respectively, for nine days. After treatment, blood samples were collected and RBC, Hb content was reckoned and remaining mice were used to assess increase in life span. Results: Ethanol extract of combination of Ziziphus mauritiana and Punica grantum manifested remarkable percentage increase in life span and notably restored RBC and Hb content towards normal. Conclusion: Ethanol extract of combination of Ziziphus mauritiana and Punica grantum exhibited significant mitigation of anaemia during cancer.

Keywords: Punica grantum L, Ziziphus mauritiana, anaemia.