Abstract

ACUTE TOXICITY STUDY OF PROCESSED SIMPSHAPA IN WISTAR RATS –AN EXPERIMENTAL STUDY

Dr. Adivesh Arakeri*, Naik N. Sameer and Hiremath R.R.

Abstract

Simpshapa is one amongst Salasaraadigana, Aasanadigana andMushkakadigana It is indicated in prameha & medoroga it effectivelydoes kapha & Medo dhatu shoshana The drugs used in the preparationof Processed Simpshapa were, Simpshapa kanda sara, Simpshapakanda twak and Simpshapa patra. Only Simpshapa kandasara & kandatwak are described in Prameha and Medo Roga in various Ayurvedicclassics. But there are many recent studies available on Anti- Diabeticactivity of Simpshapapatra. The description of the toxic signs orcomplications on combination/ Processing of all three parts together(Processed Simpshapa) are not available in classics and no any suchresearches are documented till today. In present study, Simpshapa sarais obtained by kastamarjana, to this Sara, bhavana is given with simpshapa kanda twak &patra, later dried in shade. The processed shimpshapa Choorna is administered to femalewister rats and observed for 14 days. Results: No mortality, any toxic Signs were seen in thedose of 5000mg/ kg body weight in any rats during the experimental study. None of theanimal showed any Signs of respiratory depression, Necrosis and catatonia and other toxicsigns during the experimental study. No signs of diarrhea, bloody stool, mucous in stool etcwere observed. Food consumption (10-12g/rat) and water intake (15-20ml/rat) was foundnormal throughout the completion of the study. All the animals were found active throughoutthe experimental study.

Keywords: Simpshapa, Acute toxicity study, Prameha, Medoroga, Kandasara.