Abstract

SYNTHESIS CHARACTERIZATION AND ANTIANGIOGENIC ACTIVITY OF 2-(6-SUBSTITUTED 1-3- BENZOTHIAZOL-2-YL)-N-(4- HALOPHENYL) HYDRAZINECARBOTHIOAMIDE DERIVATIVES.

Shailesh Sharma and Ved Prakash*

Abstract

Compounds having benzothiazole moiety possess diverse pharmacological activities that is antibacterial[1-2], anticonvulsant[3], antitumour[4], anti-inflammatory[5], antitubercular[6], etc. In this study a series of 2-(6-substituted 1-3- benzothiazol-2-yl)-N-(4-halophenyl) hydrazinecarbothioamide (5a-o) have been synthesized by refluxing equimolar quantity of 2-Hydrazino-6-substituted-1,3- benzothiazole (3a-e) and 4-substituted phenylisothiocyanate (4a-c). 2-Hydrazino-6- substituted-1,3- benzothiazole (3a-e) have been synthesized by refluxing of 6-substituted-1,3- benzothiazol-2-amine (2a-e)with hydrazine hydrate in the presence of con. Hydrochloric acid and ethylene glycol. 4-substituted phenylisothiocyanate (4a-c) werebprepared by reaction of 4- substituted aromatic amines with carbon disulfide in the presence of ammonia.[7] 2-(6- substituted 1-3- benzothiazol-2-yl)-N-(4-halophenyl) hydrazinecarbothioamide (5a-o) yielded according to the scheme. A number of new 2-(6-substituted 1-3- benzothiazol-2-yl)-N-(4- halophenyl) hydrazinecarbothioamide (5a-o) have been synthesized and screened for antiangiogenic activity.

Keywords: Benzothiazole, Synthesis, Antiangiogenic Activity.