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Abstract

SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME NOVEL DIARYL IMIDAZOLES AS ANTI-INFLAMMATORY AGENTS

Dushyanth Reddy Vennapu and Palled M. S.*

Abstract

The synthesis and pharmacological activity of a new series of diarylimidazoles as potent selective COX–2 inhibitor were described. QSAR based approach to screen molecules using Schrodinger Maestro program to optimize the lead compounds against the murine cyclooxygenase receptor. The best fit ligand molecules based on the dock score were synthesized characterized and evaluated for their invivo anti-inflammatory activity using carrageenan induced paw oedema.

Keywords: 1, 5 - diarylimidazoles, selective COX – 2 inhibitor, carrageenan induce paw oedema.


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