Abstract

FORMULATION AND INVITRO EVALUATION OF MUCOADHESIVE FLOATING MICROSPHERES OF REPAGLINIDE

Maheshwari K.* and Ramya Sri S.

Abstract

The purpose of this study is to formulation and invitro evaluation of gastro retentive floating microspheres of Repaglinide using solvent evaporation method. The floating microspheres were taken for micromeritic properties such as bulk density, tapped density, carrs index, hausners ratio, angle of repose. SEM studies shown that microspheres had 20 to 50 μm. the dissolution data it was evident that, formulations prepared with Eudragit S100 were revealed that formulations may not contain even 90% of drug. Hence those formulations were not considered. Formulations prepared with Ethyl cellulose was shown those contain more than 90% of drug. F5 formulation was retard the maximum drug release up to 12 hrs. Hence It was considered as optimised formulation. Optimised formula was kept for drug release kinetics. It was followed kars mayer peppas release kinetics. Optimised formulation was taken for mucoadhesion strength. Peak detachment force (N) was found to be 4.5 and work of adhesion was 16.43 mJ.

Keywords: Repaglinide, Ethyl cellulose, Eudragit S 100, Floating microspheres.