Abstract

EVALUATION OF SEVOFLURANE AND PROPOFOL’S EFFECT ON COGNITION AND MEMORY IN PATIENTS UNDERGOING LAPROSCOPIC CHOLECYSTECTOMY

Dr. Anne Feno A.*, Dr. Rajanalini N. MD, Dr. S. C. Ganesh Prabhu MD

Abstract

General anesthesia (GA) may cause post‑operative impairment of cognition and memory. This is of importance where time to discharge after anesthesia is short as after laparoscopic cholecystectomy. This study was conducted to compare the effects of propofol and sevoflurane on cognitive function in the post‑operative period. Methods: After approval of the Ethical Committee, 70 female patients posted for laparoscopic cholecystectomy to be performed under GA were randomly divided into two groups. Propofol was used in Group P and sevoflurane in Group S. Data analysis was done with California verbal learning test (CVLT), digit span test (DST), Rivermead behavioural memory test (RBMT), mini mental state examination (MMSE) score Results: Cognition and explicit memory were affected more in the propofol group in the immediate post‑operative period. Conclusion: Propofol was associated with significant impact on cognitive functions in comparison to sevoflurane in the immediate post‑operative period. Sevoflurane anesthesia might be a better option in day care surgeries.

Keywords: Anesthesia, Propofol, Sevoflurane, Cognitive function, Daycare surgery.