Abstract

6-AMINO-7-HYDROXY-4-METHYLCOUMARIN HYDRAZONES: SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY

Anees Pangal, Amol Torase, Javed Shaikh, Khursheed Ahmed and Ejazuddin Khan*

Abstract

New hydrazones, AMC1 and AMC2 were synthesized from 6-Amino- 7-hydroxy-4-methylcoumarin with two heterocyclic aldehyde and ketone. The structures of the synthesized compounds were established on the basis of physical and spectral data. They shows a prominent absorption of -(C=N-) in FTIR. Antibacterial activity of these compounds was performed on Gram +ve and Gram –ve bacteria. Both were found active against Gram +ve and Gram –ve bacteria with the Minimum Inhibitory Concentration (MIC) of 50μgmL–1. A survey of existing literature revealed that there are no reports describing the synthesis of such hydrazones.

Keywords: Hydrazone, 6-Amino-7-hydroxy-4-methylcoumarin, 7- hydroxy-4-methylcoumarin, Antibacterial.