Abstract

CYPERMETHRIN INTOXICATES TESTICULAR BIOMARKERS THROUGH OXIDATIVE STRESS IN MATURE WISTAR MALE RAT AND ZINC ALLEVIATES IT

Tuhina Das, Anurag Paramanik, Rini Ghosh, Debjani Chatterjee, Sujata Maiti Choudhury*

Abstract

Cypermethrin, a synthetic pyrethroid pesticide, is used for more thanone decade to control a wide variety of pests in agriculture. Thepresent study was designed to investigate the toxic effects ofcypermethrin on the male reproductive system of Wistar rats and alsoto assess the ameliorative role of zinc under these toxic conditions.Cypermethrin was administered alone at two dose levels and zinc waspretreated alone or combined with cypermethrin orally for 14consecutivedays. Cypermethrin reduced the testicular index, prostaticindex and epididymal index and sperm motility of rats in a dosedependent manner after the administration of cypermethrin. Significantincrease in testicular malon-di-aldehyde (MDA) and GSSG levels wereseen in the treated group whereas reduced glutathione (GSH) level oftestis were decreased significantly in a dose-dependent manner compared to the controlgroup. After the administration of cypermethrin, sperm motility, seminal plasma fructoseconcentration and testicular acid phosphatase were decreased significantly. Testicularglutamate pyruvate transaminase (GPT) and testicular glutamate oxaloacetate transaminase(GOT) levels were increased in cypermethrin intoxicated rats. The beneficial influences ofzinc in attenuating the harmful effects of cypermethrin on male reproductive system of ratwere observed in this study.

Keywords: Cypermethrin; Zinc; Sperm motility; Seminal plasma fructose concentration Testicular acid phosphatase; Antioxidant parameters.