Abstract

FORMULATION AND EVALUATION OF STABILIZED VITAMIN A PALMITATE IN MULTIVITAMIN SYRUP

M. Rajesh*, Nadar Anton Prisca Jeyapaul, P. Ramkumar and A. S. William Arputha Sundar

Abstract

In liquid oral formulations, the stability of the active and inactive ingredients is of major issue for the formulator. Usually active ingredients are less stable in aqueous formulations than in solid dosage forms. Hence it is important to stabilize and preserve the liquid oral formulations which contains water. This work was aimed to develop and stabilize Vitamin A Palmitate in a multivitamin syrup form. Three formulations (V1, V2 and V3) of Vitamin A Palmitate syrups were developed. All the formulated syrups were evaluated for appearance, colour, taste, pH, wt/ml, viscosity and drug content. Formulation V2 showed good results in terms of general, physical and chemical parameters evaluated compared to formulation V1. Hence, formulation V2 was considered as an optimized formulation. Multivitamins (Vitamin D & E) was incorporated in the optimized formulation (V3) and the stability reports of formulation V3 revealed that Vitamin A Palmitate was stable even in presence of Multivitamins.

Keywords: Multivitamins, Stabilize, Syrup, Vitamin A Palmitate.