Abstract

SPECTROPHOTOMETRIC DETERMINATION OF TOLTERODINE THROUGH ION ASSOCIATION COMPLEX REACTION IN BULK AND ITS PHARMACEUTICAL PREPARATIONS

P. V. Lakshmana Rao and C. Rambabu*

Abstract

Two spectrophotometric methods A and B have been developed for the determination of Tolterodine in bulk and dosage forms. The methods are found to be simple, sensitive, rapid and accurate. These methods are based on the formation of chloroform soluble ionassociates in the presence of acidic dyes namely Bromo Phenol Blue, BPB (Method A) and Bromo Cresol Purple, BCP (Method B) exhibiting max at 422 and 418 nm respectively. These methods obey Beer’s law in the concentration range of 2.0-10.0 μg/mL and 2.0-10.0 μg/ml. The molar absorptivities are found to be 1.42x104 and 9.61x103 L/mol. cm for methods A and B. These methods are found to be suitable for the assay of Tolterodine in pharmaceutical formulations.

Keywords: Tolterodine, BPB, BCP, Spectrophotometry.