Abstract

IN-VITRO ANTI-INFLAMMATORY AND ANTI-ARTHRITIC ACTIVITY OF N-BUTANOL FRACTION FROM TELOSMA PALLIDA (ROXB) CRAIB LEAF

Punit R. Bhatt*, Kajal B. Pandya and Navin R. Sheth

Abstract

Telosma pallida (Roxb) Craib (TP) is a perennial climber foundprominently in the region Saurashtra. Traditionally it is described toneutralize tridosha (vata, pitta, kapha). The plant is fiber-rich andedible in this region. An In-vitro anti-inflammatory activity wasevaluated for an n-butanol fraction of the TP leaf by two methods i.e.inhibition of albumin denaturation, Red Blood Cell (RBC) membranestabilization method and. An n-butanol fraction (nBF) was found toshow triterpene saponin in the qualitative phytochemical screening. Inthe present study, nBF fraction has produced inhibition up to 50.71 ± 0.36% in case of RBCmembrane lysis method with IC50 value 931.18 ± 3.82 (p<0.001), while 53.03 ± 1.06%inhibition with IC50 value 928.08 ± 20.50 (p<0.001) was found in the case of anti-proteindenaturation. Study first time demonstrated the in-vitro anti-inflammatory and anti-arthriticpotential of the T. pallida leaf.

Keywords: Pergularia pallida; anti-arthritic activity; denaturation; inflammation; HRBC.