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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

AN IMPROVED AND CONVENIENT ROUTE FOR THE SYNTHESIS OF 5-METHYL-1H-TETRAZOL-1-YL SUBSTITUTED BENZENAMINES

Suresh G. Vedpathak*, R. G. Momle, Gopal K. Kakade and Vilas S. Ingle

Abstract

An improved and convenient route for the synthesis of a series of 5-methyl-1H-tetrazol-1-yl substituted benzenamines have been reportedvia multi-step reactions from nitroanilines. 1, 5-Disubstituted tetrazolecontaining nitrobenzenes 3 have neen synthesized fromnitroacetanilides 2 by reacting with sodium azide in the presence oftitanium tetrachloride as a catalyst. The reduction of 1, 5-disubstitutedtetrazole containing nitrobenzenes 3 which on using NaBH4 gives 5-methyl-1H-tetrazol-1-yl substituted benzenamines 4 in good toexcellent yields.

Keywords: Benzenamines, Reduction, Tetrazoles, Titanium tetrachloride.

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