Abstract

ANALGESIC AND ANTI-INFLAMMATORY EFFECTS OF ETHANOL EXTRACT OF ENANTIA CHLORANTHA STEM-BARK IN RODENTS

Bassey Augustine Ini Lawrence* and Nwafor Paul Alozie

Abstract

Aim of study: To determine the anti-inflammatory, analgesic and antioxidant activities of ethanol extract of the stem bark of Enantia chlorantha in rodents in Akwa Ibom State Nigeria. Materials and methods: A one percent solution of carrageenan, xylene and fresh egg albumin were used in-vivo to test inflammation in Swiss albino mice. Acetic acid (0.1ml of 3% solution), 2.5% formalin solution (0.9% formaldehyde) made up in phosphate buffer solution (PBS concentration: NaCl 137 mM; KCl 2.7 mM and phosphate buffer 10 mM) and an electronic hot plate kept at 45± 10C throughout the experiment was used to evaluate the analgesic properties of the extract. The free radical scavenging ability of the extract against 1-Diphenyl-2- Picrylhydrazyl radical (DPPH) in methanol was evaluated. Results: The extract showed significant (p

Keywords: Enantia chlorantha, stem bark, rodents, ethanol extract.