Abstract

LUTEINIZING HORMONE AND FOLLICULAR STIMULATING HORMONE LEVELS AFTER SUCCESSFUL KIDNEY TRANSPLANTATION IN SUDANESE MALE

Shyma Mohamed Abass and Mariam Abbas Ibrahim*

Abstract

Male patients with chronic kidney disease often exhibit the biological and clinical hallmarks of an abnormal hypothalamus–pituitary–gonadal axis. It is known that dialysis does not reverse this impaired endocrine status, however the impact of kidney transplantation (KT) is still controversial. The aim of this study was to investigate the levels of serum gonadotropins (LH and FSH) after immunosuppressive drugs of KT. Methods: Descriptive analytical case control study was led in AL Khartoum state. Blood hormones levels were assayed by immunoassays in 45 men (mean age: 33 years) and at 6 months post- KT. These data were compared with those from 45 healthy men (mean age: 33 years) as controls. The main outcome measure was the between-groups differences in hormones levels. A second criterion was the comparison of patients and controls hormones levels according to the immunosuppressive drugs. Results: Serum FSH and LH level restored to the normal ranges in all kidney transplant recipients, When the correlation between the level of the reproductive hormones in kidney transplanted patients, the findings showed that a significant negative correlation (r=- 0.047, P>0.05) was found between level of LH and age of patients While a significant positive correlation (r=0.171, P>0.05) was found between level of FSH and time after transplantation, positive correlation (r=0.041, P>0.05) was found between level of LH and time after transplantation in men patients and positive correlation (r=0.21, P>0.05) was found between level of FSH and age of patients. The comparisons between levels of the LH, FSH and immunosuppressive drugs after transplantation in men patients and controls indicated increase LH in patients who they took tacrollimus drug and the levels of the FSH not significant in patients who they took cyclosporine and tacrollimus drugs. Conclusions: Successful kidney transplantation could effectively improve pituitary gonadal hormone disturbance and sexual and reproductive dysfunctions of ESRD patients.

Keywords: Kidney transplantation, Gonadotropins, LH, FSH, Cyclosporine, Tacrollimus, and Immunosuppressive Drugs.