Abstract

SPECTROSCOPIC ESTIMATION OF IBUPROFEN BULK DRUG SAMPLE USING HYDROTROPIC SOLUBILIZATION TECHNIQUE

Mishra Pooja*, Mahajan Ritu Priya, Sharma Ajay, Dr.Mahajan S.C.

Abstract

Ibuprofen, a weakly acidic, non-steroidal anti inflammatory drug having high permeability through stomach but due to its solubility limitation it can’t enter in to systemic circulation and gastric empting time ranging from 30 min to 2 hr, after this time ibuprofen goes in to small intestine where it is solubilise but can’t permeate through its membrane. The same problem arises in quantitative analysis; because of poor solubility of ibuprofen it involves organic solvents which are costly and toxic. To improve dissolution of such drug is challenging and rational. The purpose of the present study was to examine the enhancement of solubility of the Ibuprofen on addition of 1M N,Ndimethylurea (DMU) as a hydrotropic substance using a novel, safe, and sensitive method of spectroscopic estimation in ultraviolet region. beer’s low obeyed in the concentration range of 5-30μg/ml. Solubility of ibuprofen was determined with various concentrations using Spectroscopic estimation analysis. Since solubilization of non-polar drugs constitutes one of the most important tasks in formulation design, quantitative analysis and dissolution study.

Keywords: Ibuprofen, solubility enhancement, hydrotropic agents.