Abstract

MIXED POISONING OF PARAQUAT AND ORGANOPHOSPHORUS POISONINGS ASSOCIATED WITH ACCELERATED RENAL DAMAGE

Abstract

Organophosphosphates (OP) and paraquat poisoning is the major cause of death in developing countries. Very few cases reported in the literature regarding the mixed OP and paraquat poisoning and its management. In the present study we reporting a case admitted with consumption of Monocrotophos (OP compound) and Gramoxane (paraquat). Patient managed symptomatically, even though there was consistent increase in urea and creatinine levels indicating renal failure. This deterioration probably due to the effects of both compounds due to oxidative stress. Due to constant renal failure patient underwent hemodialysis along with atropine, glycopyrrolate, pralidoxime, midazolam, furosemide, immunosuppresants, antioxidants and antibiotics. There was no improvement was observed in the patient and he discharged against the medical advice.

Keywords: paraquat, op, mixed poisonings, renal failure, oxidative stress.