Abstract

FORMULATION AND EVALUATION OF GASTRORETANTIVE FLOATING TABLET USING EUDRAGIT RSPO WITH NATURAL POLYMERS

Kamlesh J. Wadher*, Shrikant W. Bute and Milind J. Umekar

Abstract

The present study involved the design of gastro retentive floating matrix tablets of weakly basic drug Domperidone by using combination of Eudragit RSPO with natural polymers Guar and Xanthan Gum. The tablets were prepared by wet granulation process. The prepared tablets were investigated for the pre-compression and post-compression parameters. FTIR and DSC studies proved that no chemical interaction in Domperidone and polymers. All the batches evaluated for swelling and floating properties also, the batches containing combination of Eudragit RSPO with natural polymers Guar and Xanthan Gum shows good swelling properties since natural gums swells rapidly and efficiently in water. The in-vitro drug release studies revealed the drug release from the formulation depended upon the polymer concentration and the polymer used. The sustained drug release with better floating was achieved with natural polymers. The developed floating tablet of Domperidone used to prolong drug release for more than 12 hrs, thereby improving bioavailability and better patient compliance. The best fitting model for all formulation was calculated. The plain polymer batches F1- F3, the best fitted models was found to be Higuchi release. The batch F4-F9 batches followed Korsmeyer peppas model.

Keywords: Domperidone, Floating tablets, Eudragit RSPO, Natural polymers, Release kinetics.