Abstract

SYNTHESIS, CHARACTERIZATION AND MICROBIOLOGICAL ACTIVITY OF 4-THIAZOLIDINONE COMPOUNDS 1-(2,4- DINITROPHENYL)-4-(SUBSTITUTEDPHENYL)-6-[2-(4- CHLOROPHENYL)-4-OXO-1,3-THIAZOLIDIN-3-YL]-3-METHYL-1,4- DIHYDROPYRANO[2,3-C] PYRAZOLE-5-CARBONITRILE

*Dr. Shaileshkumar Purshottamdas Prajapati

Abstract

A new series of 4-thiazolidinone compound was synthesized by 1- (2,4-dinitrophenyl)-4-(4-hydroxyphenyl)-6-{[(3- nitrophenyl)methylene]amino}-3-methyl-1,4-dihydropyrano[2,3-c] pyrazole-5-carbonitrile, thioglycolic acid and anhydrous zinc chloride in absolute ethanol were refluxed and then product obtained was obtained. The synthesized compounds were characterized by means of their IR, 1H-NMR spectral data and elemental analysis. All the synthesized products were evaluated for their antimicrobial activities by Cupborer method.

Keywords: thioglycolic acid, zinc chloride, Ethanol.