World Journal of Pharmaceutical Research (WJPR) has indexed with various reputed international bodies like :

WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.453

ICV : 90.8

WJPR Citation

	All	Since 2020
Citation	8502	4519
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World Journal of Pharmaceutical Research (WJPR) is giving Best Article Award in every Issue for Best Article and Issue Certificate of Appreciation to the Authors to promote research activity of scholar.

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Dr. Dhrubo Jyoti Sen
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Abstract

SYNTHESIS AND EVALUATION OF ANTIMICROBIAL & ANTIFUNGAL ACTIVITY OF NOVEL 1-CYCLOPROPYL-6 - FLUORO-7-(SUBSTITUTED AZOLE AND FUSED AZOLE)-1, 4- DIHYDRO-8-METHOXY-4-OXOQUINOLINE-3-CARBOXAMIDE DERIVATIVES

Zaki Ahmed B. Munshi and Bhata R. Chaudhari*

Abstract

One pot synthesis of 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8- methoxy-4-oxoquinoline-3-carboxamide was carried out by reacting 1- cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3- carboxylic acid with simple reagent and condition. Different novel derivatives of 7-substituted 1-cyclopropyl-6 -fluoro-1, 4-dihydro-8- methoxy-4-oxoquinoline-3-carboxamide were synthesized by substituting fluoro group at C-7 position with different azoles and fused azoles. These novel compounds were examined for their antibacterial and antifungal activities.

Keywords: Quinolones, Nalidixic acid, Carbonyldi imidazole, Antimicrobial.

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