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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIFUNGAL ACTIVITY OF 3-{4-[6-(SUBSTITUTED PHENYL)-2-THIOXO-1,2,5,6- TETRAHYDRO PYRIMIDIN-4-YL] PHENYL}-6-IODO-2-THIOXO-2,3- DIHYDROQUINAZOLIN-4-ONE DERIVATIVES.

Dr. Naresh K. Prajapati*

Abstract

Some new derivatives of 3-{4-[6-(substituted phenyl)-2-thioxo-1,2,5,6- tetrahydro pyrimidin-4-yl] phenyl}-6-iodo-2-thioxo-2,3- dihydroquinazolin-4-one have been synthesized by reacting of 3-{4- [3-(substituted phenyl) prop-2-enoyl]phenyl}-6-iodo-2-thioxo-2,3- dihydroquinazolin-4-one with thiourea and potassium hydroxide (KOH) in 30 ml of ethanol was refluxed for 3 hours. The synthesized compounds were characterized by means of their IR,1H-NMR spectral data and elemental analysis. All the compounds were tested for their antifungal activities by broth dilution method.

Keywords: quinazolin-4-one, thiourea, ethanol, IR, NMR, Antifungal activity.

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