Abstract

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF COPPER (II), COBALT (II), LEAD (II) AND MERCURY (II) COMPLEXES OF TETRA DENTATE SCHIFF BASE DERIVED FROM 5-AMINO-1, 3, 4- THIADIAZOLE-2 THIOL AND HYDANTOIN

*Dr.Mohammed.Fakruddin Ali Ahmed, V. Mahammad Yunus

Abstract

Two biologically active Schiff bases (imines) were synthesized by the reaction of 5-Amino1, 3, 4 Thiadiazole-2 Thiol with hydentoin in the presence of conc. H2SO4. The characterization of Schiff bases were carried out by using elemental analysis and VSM including IR, 1H - NMR, EI-MS analyses. The Schiff bases were checked for biological screening and found that the compound with -SH group to be more biologically active than the compound with halo (-X) group. Job’s continuous variation method and Mole ratio method revealed 1:1 metal to ligand ratio.by chelation of metals Cu (II) Co (II), Pb (II), and Hg (II) with tetra dentate complexes were synthesized.

Keywords: Tetra dentate Schiff base, 5-Amino1, 3, 4- Thiadiazole-2 Thiol and Hydentoin, VSM, Biological activity.