Abstract

METHODS FOR SYNTHESIS OF SOME ANTI-CANCER CONJUGATED AMINO ACIDS (A REVIEW)

*Farooq Ahmad Mir

Abstract

Purines are an important group of organic compounds where several compounds containing a purine residue are known to possess useful biological activity and used as antibacterial, antifungal and antitumor agents. These pharmacological properties of purines aroused our interest in synthesizing several new 6-mercaptopurine (6-MP) derivatives linked to amino acid via peptide bond with expected biological activity. 6-MP was S-alkylated by the methyl bromoacetate and then hydrolyzed with an alkaline sodium hydroxide solution to librate the free carboxylic group side chain. Also the alkylated 6-MP reacted with hydrazine hydrate to get hydrazide of 6-MP. Conventional solution method for peptide synthesis used as a coupling method between the free carboxyl and amine groups. The proposed analogues were successfully synthesized and their structural formulas were consistent with the proposed structures as they were characterized and proved by thin layer chromatography (TLC), melting point, infrared spectroscopy (IR) and elemental microanalysis.

Keywords: mercaptopurine, methyl bromoacetate, antitumor agents.