Abstract

FABRICATION OF SUSTAINED RELEASE MATRIX TABLET FORMULATION OF METOPROLOL SUCCINATE USING PVAP

Abhijit N. Merekar and Bhanudas S. Kuchekar

Abstract

The present study was conducted to investigate the effect of PVAP at different concentrations on the release profile of Metoprolol Succinate from matrix tablets. Matrix-based tablet using different concentrations of PVAP was developed using direct compression technique to contain 47.50 mg of Metoprolol Succinate . The pre-compression and post compression parameters were evaluated. Formulations were evaluated for the release of Metoprolol Succinate over a period of 12 h in pH 6.8 phosphate buffer using USP type II dissolution apparatus. Metoprolol Succinate and pure PVAP compatibility interactions was investigated by using Fourier-transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC). Formulation was optimized on the basis of acceptable tablet properties and in vitro drug release. The f2 similarity factor for F5 of 78.65 shows drug release pattern very close to marketed product release profile . The in vivo X-ray studies were carried out to confirm the release pattern in vivo in rabbits, the studies showed that the sustaining activity where achieved by adhering to various sites in the gastrointestinal tract for the period of 12 h. The in vitro release profile and the mathematical models indicate that release of Metoprolol Succinate can be effectively controlled from a single tablet using PVAP matrix system.

Keywords: Metoprolol Succinate ,PVAP, Matrix system.