Abstract

COPPER AND PAEDIATRIC NEUROLOGICAL DISORDERS: A MINIREVIEW

Tamer Rizk* MD FRCPCH(UK)

Abstract

Copper is one of the essential elements for maintaining normal physiological activity of multiple essential enzymes as cytochrome coxidase, superoxide-dismutase and dopamine-β-hydroxylase. Enzymes deficiencies result in severe neurological symptoms and serious neurological diseases, some of them has been present for more than a century now. In this mini-review, I aim to provide a synopsis of current knowledge regarding copper related disorders and available lines of management which may improve the overall outcome in case of early recognition and prompt intervention.

Keywords: Copper, Wilson, Menkes, occipital horn, MEDNIK.