Abstract

“PHARMACOGENOMICS CURRENT SCENARIO: CLINICAL APPLICATIONS AND CHALLENGES”

Dr. Supriya Rajeev Ambedkar* and Dr. Pramila Yadav

Abstract

Variability in Drug response is major and one of the most important Challenges faced by the Clinicians in todays’ practice. Adverse Drug reactions contribute significantly in Mortality and Morbidity all over the world. Most of these can be avoided by means of applications of Pharmacogenomics. Clinical Applications of Pharmacogenomics have helped Clinicians to replace traditional drug regimens to more safe and customized drug regimens. Pharmacogenomics applications are also seen in research at earlier stages of drug trials for development of more targeted drugs. This article aims at providing an update about information on pharmacogenomics’ current applications in clinical medicine and also informs about the Pharmacogenetics of certain Idiosyncratic Adverse Drug Reactions so far proved. This article introduces the Concept of Individualized medicine endorsing more Customized Rational Use of drugs as well as discusses the Current challenges in Implementation of Pharmacogenomics in clinical practice as well in Research.

Keywords: Pharmacogenomics; Individualized medicine; Variability in Drug response; Adverse Drug Reactions; Rational use of drugs.