Abstract

RECEPTOR TARGETED NANOMEDICINE AS EMERGING PLATFORM FOR BRAIN CANCER THERAPY

Abhishesh Kumar Mehata*, Tarkeshwar Dubey, Kancharla Bhanukiran, Deepa Dehari, Vishnu Priya and Madaswamy S. Muthu

Abstract

Brain cancer remain as most challenging area in the oncology due to high rate of reoccurrence and poor prognosis. Many combined therapies have been approached like chemotherapy, radiotherapy followed by surgical resection but failure in the delivery of chemotherapeutics at the tumor site remained as challenging task due to presence of blood brain barrier (BBB), efflux transport process. In order to solve these problems targeted nanomedicine emerged as promising drug delivery system with view of manipulating endogenous transport system to overcome BBB permeability. Some of the key cell surface molecules that have been identified as Glioblastoma (GBM) targets for brain cancer therapy include the transferrin receptor, lowdensity lipoprotein receptor-related protein, αvβ3 integrin, glucose transporter(s), epidermal growth factor receptor (EGFR), interleukin-13 receptor α chain variant 2, with the help of receptor targeted drug delivery system chemotherapeutics can be delivered at targeted site of tumor.

Keywords: Nanomedicine, Oncology, Glioblastoma, Proliferation.