Abstract

IN VITRO ANTI INFLAMMATORY ACTIVITY OF STEM OF ZANTHOXYLUM RHETSA (ROXB.) DC.

S. Parthiban*, K. Gopalasathees Kumar, T. Boopathi, G. Sangeetha, M. Thanga Kokila and V. Sanish Devan

Abstract

Zanthoxylum rhetsa (Roxb.) DC. is a valuable medicinal plant which has been valuable for centuries in ayurvedic medicine. Phytochemical analysis of Z.rhetsa (Roxb.) DC. stem extracts revealed the presence of various bio chemical compounds such as flavonoids, glycosides, alkaloids, aleurone, starch, amino acids, lignin, volatile oil, fats and fixed oils, mucilage, pectins, proteins, steroids and triterpenoids. Since glycoside and flavonoids have remarkable anti-inflammatory activity. Our present work aims at evaluating the in vitro anti in-flammatory activity of Zanthoxylum rhetsa (Roxb.) DC. by protein denaturation and HRBC method. Denaturation of protein is a well-documented cause of inflammation and rheumatoid arthritis. The data of our studies suggests that Zanthoxylum rhetsa (Roxb) DC. of stem extract showed significant anti- inflammatory activity.

Keywords: Zanthoxylum rhetsa, anti-inflammatory, HRBC method, flavonoid.