Abstract

“DESIGN AND EVALUATION OF EXTENDED RELEASE FORMULATIONS OF METOPROLOL SUCCINATE USING COMBINATION OF FENUGREEK GUM WITH OTHER POLYMERS”

Sunil H.J.,*Ashwini Rajendra and Suresh K.

Abstract

The present work was an effort to develop matrix type extended release tablets of Metoprolol succinate. Matrix tablets of Metoprolol succinate were prepared by using primary natural polymer fenugreek gum and secondary polymer Guar gum and HPMC K4M. Compatibility between drug and polymer was evaluated by FTIR. Matrix tablets were evaluated for pre and post formulation studies. The prepared formulations showed satisfactory pre and post compression parameters. The in-vitro drug release from formulation F1 to F11 ranged from 92.31% to 108.41%. The drug release for the formulations F3 and F11 followed first order with non fickian anomalous diffusion mechanism. The model independent parameters for formulation F3 and F11 were found to be 67.11 and 55.02 % in 9hrs. It was concluded that matrix tablets of Metaprolol succinate were successful in extending the drug release for 12 hrs and the formulations were stable for the duration of the study.

Keywords: Extended release, Metaprolol succinate, Fenugreek gum, HPMC K4M, wet granulation, compression coating.