Abstract

ANTI-OXIDANT STUDY OF AN HERBOMINERAL HEPATOPROTECTIVE COMPOUND YAKRITSHULA VINASHINI VATIKA

Dr. Anita Mali*, Dr. Prakash Jondhale, Dr. Sanjay Kumar, Dr. Parimi Suresh

Abstract

Yakritshula Vinashini Vatika (YSV), mentioned in Bhaishajya Ratnavali, is a herbo-mineral compound used in the management of Liver Diseases. It is a combination of Navasadara and Saindhava lavana and 6 herbal ingredients with Putikambu (Chirabilva swarasa) levigation. Liver diseases are considered as fatal and life threatening. Natural functions of the liver include secretion of bile salts and pigments and also digestion of fats. Not only this, the liver actually fights toxins naturally. The toxins immediately get spread in the body through blood. According to Ayurvedic point of view antioxidants can be used for Rasayana treatment for longevity of life, delaying of ageing and improving the health status of an individual. Antioxidants are molecules that slow or prevent the oxidation of other chemicals by neutralizing free radicals by accepting or donating an electron to eliminate the unpaired condition. Antioxidant activity of methanolic extract of Yakritashula vinashini vatika was evaluated by calculating the free radical scavenging activity of that drug using DPPH scavenging, Nitric oxide radical scavenging and reducing power. The results were compared with standard at different concentration of Ascorbic Acid (20, 40, 60, 80, 100 μg). The strength of YSV methanolic extract in DPPH, Nitric oxide radical scavenging and reducing power assay methods of 100 μg concentration were 75.54%±0.875(Ascorbic Acid-94.23%±0.532), 66.97%±0.236 (Ascorbic Acid- 84.45%±0.328) and 0.28±0.0096 (Ascorbic acid 0.30±0.0001) respectively. Extract of Yakritashula vinashini vatika showed significant antioxidant activity in all the concentrations.

Keywords: Yakritshula vinashini vatika, Herbomineral compound, Antioxidant property.