Abstract

EVALUATION OF ANTIDEPRESSANT POTENTIAL OF ETHANOLIC EXTRACT OF PASPALUM SCROBICULATUM LINN.

Swati Sharma* and Dr. Jyoti Saxena

Abstract

Objective: Paspalum scrobiculatum (P. scrobiculatum) is a millet variety, cultivated throughout India having different pharmacological properties like antidiabetic, anti-inflammatory, hopolipidaemic, antirheumatic and wound healing. Various bioactive components from plant origin are studied to access their role in neurodegenerative diseases. In this study, the antidepressant effect of ethanolic extract of P. scrobiculatum (EEPS) grains was studied in mice. Method: Forced swimming test (FST) and tail suspension test (TST) were used to determine the antidepressant effect of 200 and 400 mg/kg EEPS grain extracts by oral administration to mice. Imipramine (30 mg/kg) was used as standard drug. Result: The results showed that doses, 200 mg/kg and 400 mg/kg ethanolic extracts showed antidepressant effect by significantly reducing the immobility time compared to vehicle (P

Keywords: Depression, Forced swim test (FST), Immobility time, Paspalum scrobiculatum, Tail suspension test (TST).