Abstract

A PROSPECTIVE RANDOMISED STUDY COMPARING THE PREEMPTIVE ANALGESIC EFFECTS OF ORAL GABAPENTIN WITH ORAL CLONIDINE ON INTUBATION RESPONSE AND POST OPERATIVE ANALGESIC REQUIREMENT FOR PATIENTS UNDERGOING LAPAROSCOPIC CHOLECYSTECTOMY.

Dr. Kokila, Dr. Selvamani and Dr. Juvairiya Banu*

Abstract

The aim of this study is to compare the effects of Oral Gabapentin and Oral Clonidine as pre-emptive analgesic, on attenuation of the intubation response and postoperative analgesic requirement in patients undergoing Laparoscopic cholecystectomy. In this prospective randomized case control study with respect to a placebo, seventy five patients satisfying the inclusion criteria were randomly divided into three groups of twenty five each. Group A received Gabapentin, Group B received Clonidine, Group C received Placebo of Vitamin C tablet 90 minutes prior to induction. By adding Gabapentin and Clonidine orally 90 minutes preoperatively, it reaches peak concentration in plasma at the onset of surgical stimulus thereby inhibiting central and peripheral neuronal sensitization to pain. Thereby it reduces intubation response, post-operative pain intensity and analgesic prerequisites. Intraoperatively patients were monitored for Heart rate, Systolic blood pressure, diastolic blood pressure and Mean arterial pressure during intubation and post-operatively monitored for sedation, anxiety level, VAS score, total analgesic requirement and RPP (RATE PRESSURE PRODUCT) for 8 hours. As changes in vital parameters were lower in patients with Oral clonidine, it was found to be slightly better than Gabapentin in attenuating the haemodynamic stress response to laryngoscopy and intubation. Ramsay sedation scores were higher in patients with oral Gabapentine compared to the other two groups, so Gabapentin was found to be slightly better than Clonidine in providing post-operative pain relief.

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