Abstract

DESIGN OPTIMIZE AND EVALUATION OF FLOATING MICROSPHERES BY SOLVENT EVAPORATION TECHNIQUE OF ANTIULCER DRUG.

Devendra Sharma*, M.D. Godbole and Sushil Burle

Abstract

Oral controlled release dosage forms have been extensively used to improve therapy of many important medications. In this we mostly focused on Gastro retentive floating microsphere containing Lafutidine, a second generation histamine H 2 –receptor antagonist were prepared by solvent evaporation technique using HPMC K 15, Ethyl cellulose, EUDRAGIT® S 100, EUDRAGIT® L 100. The main objective of study to develop floating controlled drug delivery system that can provide therapeutically effective plasma drug concentration levels for longer durations. Which reduces the dosing frequency and minimized fluctuations in order to enhance the drug bioavailability. The prepared microsphere were evaluated for micromeritics study, percentage yield, in- vitro floating ability, in- vitro drug release and stability studies. The optimized formulation showed good floating for 8 hr. in vitro studies. The formulation stable at the end of 45 days with carried out by evaluated all the studies.

Keywords: Microsphere, Lafutidine, EUDRAGIT® S 100, EUDRAGIT® L 100.