Abstract

ANTI-DIABETIC ACTIVITY OF METHANOLIC EXTRACT OF ANOGEISSUS LATIFOLIA WALL IN SWISS ALBINO RATS

A.Rajani, M.VishnuVardhan Reddy*, K.Hemamalini

Abstract

The Anti-Diabetic activity of methanolic extract of Anogeissus latifolia Wall (combretaceae) was investigated in Alloxan induced diabetic albino rats and extract was compared with the standard using Metformin. Anogeissus latifolia is widely used in traditional system of medicine to treat diabetes in India. The Methanolic extract (300mg/kg) of leaves was taken to evaluate the antidiabetic activity against normal and alloxan induced diabetic rats. Oral administration of the methanolic extract for 21 days resulted in a significant reduction in blood glucose level. The extract has decreased the level of serum cholesterol, triglycerides, creatinine, urea and alkaline phosphatase significantly, but the level of HDL and total protein were found to be increased after treatments. Thus the study has shown the antidiabetic action of Anogeissus latifolia, and should further be subjected to bioactivity guided drug discovery to isolate a lead compound responsible for this activity.

Keywords: Anogeissus latifolia, Anti-Diabetic activity, Alloxan, Acute oral toxicity.