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Abstract

HIGH GENITOURINARY CARRIAGE OF METHICILLINRESISTANT STAPHYLOCOCCUS AUREUS AMONG PREGNANT WOMEN ATTENDING ANTE-NATAL CLINICS AT MATER MISERICORDIA HOSPITAL, AFIKPO, EBONYI STATE, NIGERIA.

Ayogu, T.E., Orji, J.O*., Nwabugwu, C.C., Nnachi, A.U., Aghanya, I.N., Efunshile, A.M., Nnemelu, P.O., Okeh, C.O., Uzoh, C.V. and Asobie, G.C.

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a worldwide human pathogen of enormous public health concern, causing severe morbidity and mortality both in hospitals and the community. Their presence in pregnancy condition is a cause for concern. This study investigated the prevalence and antibiotics susceptibility pattern of urinary methicillin-resistant Staphylococcus aureus among pregnant women attending ante-natal clinics at Mater Misericordia Hospital Afikpo. Midstream urine samples (n=89) were collected from these women and analyzed in the Department of Applied Microbiology Laboratory, Ebonyi State University, Abakaliki, using standard microbiological techniques. Fifty-four (60.67%) pregnant women were found to harbor S. aureus and out of these, forty-five (83.33%) were positive for methicillin-resistance. The results of the antibiotic susceptibility testing revealed varying degrees of susceptibility to amoxicillin (26%), oxacillin (0%), erythromycin (33%), ceftriaxone (4%), clindamycin (33%), meropenem (100%), ofloxacin (44%), gentamicin (62%), tetracycline (17%), cefotaxine (24%), ciprofloxacin (77%) and perfloxacin (71%). The multidrug-resistant index (MDRI) of the MRSA isolates ranged from 0.16 to 0.75. This work revealed high prevalence of MRSA among pregnant women in this area and suggest a possible picture of the state of other pregnant women at the rural communities of the state and the country at large. To avert possible maternal and foetal complications due to this organism, routine screening through the gestation period and prompt treatment of cases are hereby recommended. Also, the need for public enlightenment of the implication of abuse and misuse of drugs cannot be over-emphasize in the fight against drug resistance.

Keywords: MRSA, antenatal, multi-drug resistance, prevalence, Staphylococcus aureus.


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